Title

Characterization of DNA Lesions Produced from the Reaction of Diols and 5-Formylcytosine

Lead Author Affiliation

Chemistry

Introduction

The DNA base cytosine is commonly methylated in the promoter regions of inactive genes, indicating that methylation serves as a mechanism of control of gene expression. Methylated cytosine can also be oxidized to form other bases such as 5-formylcytosine, a reactive molecule. Molecules such as 1,3-propanediol, a compound commonly found in antifreeze and textiles, could react with the formyl group of 5-fC to form a cyclic acetal lesion.

Location

DUC Ballroom A&B

Format

Poster Presentation

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Apr 30th, 1:00 PM Apr 30th, 3:30 PM

Characterization of DNA Lesions Produced from the Reaction of Diols and 5-Formylcytosine

DUC Ballroom A&B

The DNA base cytosine is commonly methylated in the promoter regions of inactive genes, indicating that methylation serves as a mechanism of control of gene expression. Methylated cytosine can also be oxidized to form other bases such as 5-formylcytosine, a reactive molecule. Molecules such as 1,3-propanediol, a compound commonly found in antifreeze and textiles, could react with the formyl group of 5-fC to form a cyclic acetal lesion.