Title

NLRX1 modulates the balance between NLRP3 inflammasome activation and NF-kB signaling during Fusobacterium nucleatum infection

Lead Author Affiliation

Biomedical Sciences

Introduction

NOD-like receptors (NLRs) play an important role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, modulates mitochondrial ROS (mROS) generation, which activates the NLRP3 inflammasome. However, the role of NLRX1 in NLRP3 inflammasome activation has not been examined. Therefore, we intend to investigate whether NLRX1 plays a role in NLRP3 inflammasome activation in periodontitis.

Location

DUC Ballroom A&B

Format

Poster Presentation

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Apr 30th, 10:00 AM Apr 30th, 12:00 PM

NLRX1 modulates the balance between NLRP3 inflammasome activation and NF-kB signaling during Fusobacterium nucleatum infection

DUC Ballroom A&B

NOD-like receptors (NLRs) play an important role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, modulates mitochondrial ROS (mROS) generation, which activates the NLRP3 inflammasome. However, the role of NLRX1 in NLRP3 inflammasome activation has not been examined. Therefore, we intend to investigate whether NLRX1 plays a role in NLRP3 inflammasome activation in periodontitis.