Title

Determination of Permeability under Non-Steady State

Poster Number

23

Lead Author Affiliation

Dept. of Pharmaceutics & Medicinal Chemistry

Introduction

Permeability is an important parameter in drug formulation and pharmacokinetics modeling. It is usually determined under Dirichlet boundary condition after reaching steady state. The traditional assay is time consuming.

Purpose

Estimate permeability under non-steady state.

Method

Non-linear regression program based on numerical Laplace transform and global optimization was developed to estimate permeability under unsteady state. The program is flexible with different boundary conditions. The performance of the program under Dirichlet and finite volume boundary conditions were validated by using simulated data. The proposed method was compared to the traditional method with lidocaine experimental data.

Results

The validation results showed the parameter estimation using our program is robust. The relative error is less than 0.2; CV% is less than 0.2%; R2 is 0.999. The parameter estimation results obtained from non-steady state data is within twice of that obtained from steady state data.

Significance

First, no commercial software is available for parameter estimation of partial differential equations. Second, this is the first method to determine permeability under non-steady state. In addition, it is friendly to different boundary conditions. Compared to the traditional assay performed under steady state, the proposed method is more efficient and flexible. It could greatly shorten experimental time period and reduce cost.

Location

DeRosa University Center, Stockton campus, University of the Pacific

Format

Poster Presentation

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Apr 25th, 10:00 AM Apr 25th, 12:00 PM

Determination of Permeability under Non-Steady State

DeRosa University Center, Stockton campus, University of the Pacific

Permeability is an important parameter in drug formulation and pharmacokinetics modeling. It is usually determined under Dirichlet boundary condition after reaching steady state. The traditional assay is time consuming.