Title

Naturally occurring molecule, caftaric acid, found in grapes and wine, for use as a transthyretin stabilizing agent

Poster Number

7

Lead Author Affiliation

Pharmaceutical and Chemical Sciences

Introduction

As more attention is raised to transthyretin amyloidosis diseases, molecules that are safe and efficacious are desired for ameliorating their effects.

Purpose

Candidates currently under review have lacked in their efficacy (Tafamidis) or their relative safety (Diflunisal), which leaves patients with few options.

Method

Here we provide evidence that caftaric acid, which is found in high abundance in grapes, raisins, and wine, may be used as a safe and natural transthyretin stabilization agent.

Significance

We present that caftaric acid, at naturally occurring levels in wine and grape juice, binds with high affinity and selectivity in vitro, and attempt to show caftaric acid’s potential as a therapeutic.

Location

DeRosa University Center, Stockton campus, University of the Pacific

Format

Poster Presentation

This document is currently not available here.

Share

COinS
 
Apr 25th, 2:00 PM Apr 25th, 4:00 PM

Naturally occurring molecule, caftaric acid, found in grapes and wine, for use as a transthyretin stabilizing agent

DeRosa University Center, Stockton campus, University of the Pacific

As more attention is raised to transthyretin amyloidosis diseases, molecules that are safe and efficacious are desired for ameliorating their effects.