Title

EFFICIENT CELLULAR DELIVERY OF METHOTREXATE BY LIPOSOMES CONTAINING NOVEL AMPHIPHILES WITH pH-TRIGGERABLE CONFORMATIONS

Lead Author Affiliation

Chemistry

Second Author Affiliation

Chemistry

Third Author Affiliation

Chemistry

Fourth Author Affiliation

Chemistry

Fifth Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Sixth Author Affiliation

Chemistry

Introduction

Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and inflammation sites. Liposomes are made mostly of lipid molecules with incorporation of other components.

Purpose

Development of a novel type of pH(acid)-sensitive liposomes for targeted drug delivery.

Method

We suggested recently a novel type of pH-sensitive drug delivery system, “fliposomes”, which contain trans-2-aminocyclohexanol-based amphiphiles, “flipids”, that perform a conformational flip (a drastic change of molecular shape) and trigger an instant cargo release in acidic media. Here we report our latest studies on the cellular uptake of the methotrexate-loaded fliposomes.

Results

A series of new flipids has been synthesized, and the cellular uptake in HeLa and B16F1 cancer cells of the methotrexate-loaded fliposomes has been studied.

Significance

New type of acid-sensitive liposomes can serve as viable drug delivery systems in cancer treatment and other areas of medicine.

Location

DeRosa University Center, Stockton campus, University of the Pacific

Format

Poster Presentation

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Mar 25th, 10:00 AM Mar 25th, 3:00 PM

EFFICIENT CELLULAR DELIVERY OF METHOTREXATE BY LIPOSOMES CONTAINING NOVEL AMPHIPHILES WITH pH-TRIGGERABLE CONFORMATIONS

DeRosa University Center, Stockton campus, University of the Pacific

Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and inflammation sites. Liposomes are made mostly of lipid molecules with incorporation of other components.