Title

NOVEL AMPHIPHILES FOR pH-SENSITIVE LIPOSOMES WITH TRANS-2-AMINOCYCLOHEXANOL-BASED CONFORMATIONAL SWITCH

Lead Author Affiliation

Chemistry

Second Author Affiliation

Chemistry

Third Author Affiliation

Chemistry

Fourth Author Affiliation

Chemistry

Fifth Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Sixth Author Affiliation

Chemistry

Introduction

Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and inflammation sites. Liposomes are made mostly of lipid molecules with incorporation of other components.

Purpose

Development of a novel type of pH(acid)-sensitive liposomes for targeted drug delivery.

Method

We suggested recently a novel type of pH-sensitive drug delivery system, “fliposomes”, which contain trans-2-aminocyclohexanol-based amphiphiles, “flipids”, that perform a conformational flip (a drastic change of molecular shape) and trigger an instant cargo release in acidic media. The present research has focused on development and studies of such flipids.

Results

A series of new flipids has been synthesized, and a good correlation between their conformational switch and the leakage of drugs from fliposomes has been observed. The diethyl esters of similar structure were shown to be good models for prediction of the flipids’ conformational behavior.

Significance

New type of acid-sensitive liposomes provides a prospective drug delivery system for application in cancer treatment and other areas of medicine.

Location

DeRosa University Center, Stockton campus, University of the Pacific

Format

Poster Presentation

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Mar 25th, 10:00 AM Mar 25th, 3:00 PM

NOVEL AMPHIPHILES FOR pH-SENSITIVE LIPOSOMES WITH TRANS-2-AMINOCYCLOHEXANOL-BASED CONFORMATIONAL SWITCH

DeRosa University Center, Stockton campus, University of the Pacific

Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and inflammation sites. Liposomes are made mostly of lipid molecules with incorporation of other components.