Title

Delay or inhibition of rat lens opacification using pantethine and WR77913

ORCiD

0000-0001-9010-5970

Document Type

Article

Publication Title

Experimental Eye Research

ISSN

0014-4835

Volume

62

Issue

1

DOI

10.1006/exer.1996.0009

First Page

75

Last Page

84

Publication Date

1-1-1996

Abstract

Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons. In the radiation or selenite models, each test reagent was administered 15 to 30 min prior to initiation of cataract by a single injection of Na2SeO3 or a single exposure to 15 Gy (gray) gamma radiation. In the galactose, streptozotocin and Royal College of Surgeons models where the cataractogenic insult was continuous, repeated administrations of pantethine and WR-77913 were necessary. The results suggested that protein aggregation and lens opacification associated with a variety of physiological and biochemical mechanisms can be delayed or inhibited using a systemic administration of pantethine or WR-77913.