Title

Enhancement of fast neutron beams with Boron Neutron Capture Theory: A mechanism for achieving a selective, concomitant tumor boost

ORCiD

0000-0001-9010-5970

Document Type

Article

Publication Title

Acta Oncologica

ISSN

0284-186X

Volume

33

Issue

3

DOI

10.3109/02841869409098422

First Page

307

Last Page

307

Publication Date

1-1-1994

Abstract

Both fast neutron radiotherapy and boron neutron capture therapy (BNCT) have been utilized to treat malignant disease. Herein we discuss the potential of combining these treatments to enhance the effectiveness of fast neutron therapy through a concomitant BNCT boost. Using a fast neutron beam generated from a 50 MeV proton on beryllium reaction, we have determined that 0.1% of the beam per microgram of boron-10 per gram of tissue (microgram/g) can be deposited via BNCT. Our mathematical modeling predicts that BNCT enhancement of our beam will lead to an additional 1-2 logs of tumor cell kill for boron-10 concentrations of 30-50 micrograms/g. We have validated this via V-79 cell line in vitro measurements. A Poisson model estimation of how this additional cell kill will influence local tumor control, predicts that BNCT enhancement of fast neutron radiation will lead to a clinically significant improvement in outcome.

Comments

Presented at the Nordic Conference on Neutrons in Research and Cancer Therapy, 29-30 April, 1993, Linkoping, Sweden