Title

Magnetic resonance spectroscopic measurement of cellular thiol reduction-oxidation state

ORCiD

0000-0001-9010-5970

Document Type

Article

Publication Title

International Journal of Radiation Oncology - Biology - Physics

ISSN

0360-3016

Volume

22

Issue

4

DOI

10.1016/0360-3016(92)90518-M

First Page

755

Last Page

757

Publication Date

1-1-1992

Abstract

Chromatographic and magnetic resonance spectroscopic measurements of thiol reduction-oxidation state in chemically constructed samples show close analytical agreement. This result, coupled with the synthesis of new probe molecules allowing greater sensitivity and lower toxicity, supports the development of an NMR method for non-invasive thiol redox measurement, an important variable in the response of tumors to radiation and chemotherapy.