ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

PLoS One

ISSN

1932-6203

Volume

7

Issue

8

DOI

10.1371/journal.pone.0042266

First Page

1

Last Page

15

Publication Date

8-1-2012

Abstract

Infection with pathogenic Leptospira species causes serious systemic inflammation in patients. Although a few leptospiral proinflammatory molecules have been identified, Leptospira likely encodes other unidentified strong inflammation stimulators. The pathogenic L. interrogans genome encodes numerous putative hemolysin genes. Since hemolysins from other bacteria can cause inflammatory reactions, we hypothesized that leptospiral hemolysins may function as proinflammatory stimulators that contribute to the strong inflammation associated with Leptospira infection.

Comments

Article e42266

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