Title

Is the inflammasome relevant for epithelial cell function?

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Microbes and Infection

ISSN

1286-4579

Volume

18

Issue

2

DOI

10.1016/j.micinf.2015.10.007

First Page

93

Last Page

101

Publication Date

2-1-2016

Abstract

Inflammasomes are intracellular protein complexes that sense microbial components and damage of infected cells. Following activation by molecules released by pathogens or injured cells, inflammasomes activate caspase-1, allowing secretion of the pro-inflammatory cytokines IL-1β and IL-18 from innate immune cells. Inflammasomes are also expressed in epithelial cells, where their function has attracted less attention. Nonetheless, depending on the tissue, epithelial inflammasomes can mediate inflammation, wound healing, and pain sensitivity. We review here recent findings on inflammasomes found in epithelial tissues, highlighting the importance of these protein complexes in the response of epithelial tissues to microbial infections.