Title

Cell death mechanisms and the immune system

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Immunological Reviews

ISSN

0105-2896

Volume

121

Issue

1

DOI

10.1111/j.1600-065X.1991.tb00822.x

First Page

29

Last Page

65

Publication Date

6-1-1991

Abstract

The immune system offers good models in many fields of cell biology, including cell death. On the one hand, considerable cell death occur in the immune system, where it seems related to its development. On the other, cell death is also caused by the immune system and is then related to its function. This review will analyze some models of cell death related to the immune system and will attempt, in particular, to describe for each model an intracellular sequence of events leading to cell death; to distinguish, within this sequence, steps belonging to control or to effector mechanisms; and to underline, whenever possible, clues regarding the nature of the molecules casually involved in the dying cell.