Title

Host-cell survival and death during Chlamydia infection

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Current Immunololgy Reviews

ISSN

1573-3955

Volume

3

Issue

1

DOI

10.2174/157339507779802179

First Page

31

Last Page

40

Publication Date

1-1-2007

Abstract

Different Chlamydia trachomatis strains are responsible for prevalent bacterial sexually-transmitted disease and represent the leading cause of preventable blindness worldwide. Factors that predispose individuals to disease and mechanisms by which chlamydiae cause inflammation and tissue damage remain unclear. Results from recent studies indicate that prolonged survival and subsequent death of infected cells and their effect on immune effector cells during chlamydial infection may be important in determining the outcome. Survival of infected cells is favored at early times of infection through inhibition of the mitochondrial pathway of apoptosis. Death at later times displays features of both apoptosis and necrosis, but pro-apoptotic caspases are not involved. Most studies on chlamydial modulation of host-cell death until now have been performed in cell lines. The consequences for pathogenesis and the immune response will require animal models of chlamydial infection, preferably mice with targeted deletions of genes that play a role in cell survival and death.