Title

MHC and MHC-related proteins as pleiotropic signal molecules

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

FASEB Journal

ISSN

0892-6638

Volume

16

Issue

2

DOI

10.1096/fj.01-0758com

First Page

202

Last Page

206

Publication Date

2-1-2002

Abstract

Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHC-related molecules have a much more varied function in the body. Many of these molecules are involved in pleiotropic interactions with other proteins, which initiate signal transduction cascades and contribute to cellular and tissue homeostasis.