Title

Alternative functions for the multifarious inflammasome

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Biomedical Journal

ISSN

2319-4170

Volume

39

Issue

3

DOI

10.1016/j.bj.2016.06.001

First Page

183

Last Page

187

Publication Date

6-1-2016

Abstract

The inflammasome has been mainly studied in innate immune cells in which it senses microbes and cellular damage, and induces secretion of pro-inflammatory cytokines. This process induces an inflammatory response that is critical for the resolution of infections and repair of tissue damage following injury. Recent studies indicate that inflammasome complex formation also participates in many other cellular and physiological processes beyond modulation of inflammation, such as autophagy, metabolism, eicosanoids production, and phagosome maturation.