Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells

Authors

Matthew A. Pettengill, University of California, Merced
Verissa W. Lam, University of California, Merced
Ikechukwu Ollawa, University of California, Merced
Camila Marques-da-Silva, University of California, Merced
David M. Ojcius, University of California, MercedFollow

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

PLoS One

ISSN

1932-6203

Volume

7

Issue

10

DOI

10.1371/journal.pone.0048456

First Page

1

Last Page

4

Publication Date

10-30-2012

Abstract

Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.

Comments

Article e48456

Recommended Citation

Pettengill, M. A., Lam, V. W., Ollawa, I., Marques-da-Silva, C., & Ojcius, D. M. (2012). Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells. PLoS One, 7(10), 1–4. DOI: 10.1371/journal.pone.0048456
https://scholarlycommons.pacific.edu/dugoni-facarticles/146