Title

NMR investigation of phospholipid/PEG-ceramide-liposomes

Document Type

Conference Presentation

Department

Chemistry

Conference Title

241st American Chemical Society (ACS) National Meeting & Exposition

Organization

American Chemical Society (ACS)

Location

Anaheim, CA

Conference Dates

March 27-31, 2011

Date of Presentation

3-28-2011

Abstract

Liposomes are macromolecular structures in which an aqueous core is surrounded by a double-layered lipid membrane. Surface modifications in liposomes serve the purpose of enhanced water-solubility, immuno-compatibility, and targeted delivery of liposome “cargo”, e.g. drugs or DNA/RNA. Liposomal drug delivery systems are frequently composed of phospho-lipids and ceramides amongst others. We investigated pH-sensitive liposomes. Complete NMR structure assignment and quantification of all components provided quality control. During liposome extrusion/preparation/loading and cleanup, little to no variation in composition was observed.

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