NMR investigation of phospholipid/PEG-ceramide-liposomes

Authors

Andreas H. Franz, University of the PacificFollow
Nataliya M. Samoshina, University of the PacificFollow
Xin Guo, University of the PacificFollow
Vyacheslav V. Samoshin, University of the PacificFollow

Document Type

Conference Presentation

Department

Chemistry

Conference Title

241st American Chemical Society (ACS) National Meeting & Exposition

Organization

American Chemical Society (ACS)

Location

Anaheim, CA

Conference Dates

March 27-31, 2011

Date of Presentation

3-28-2011

Abstract

Liposomes are macromolecular structures in which an aqueous core is surrounded by a double-layered lipid membrane. Surface modifications in liposomes serve the purpose of enhanced water-solubility, immuno-compatibility, and targeted delivery of liposome “cargo”, e.g. drugs or DNA/RNA. Liposomal drug delivery systems are frequently composed of phospho-lipids and ceramides amongst others. We investigated pH-sensitive liposomes. Complete NMR structure assignment and quantification of all components provided quality control. During liposome extrusion/preparation/loading and cleanup, little to no variation in composition was observed.

Comments

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Recommended Citation

Franz, A. H., Samoshina, N. M., Guo, X., & Samoshin, V. V. (2011). NMR investigation of phospholipid/PEG-ceramide-liposomes. Paper presented at 241st American Chemical Society (ACS) National Meeting & Exposition in Anaheim, CA.
https://scholarlycommons.pacific.edu/cop-facpres/351