Title

Thio-β-D-glucosides: Synthesis and evaluation as glycosidase inhibitors and activators

Document Type

Poster

Department

Chemistry

Conference Title

248th American Chemical Society (ACS) National Meeting

Organization

American Chemical Society (ACS)

Location

San Francisco, CA

Conference Dates

August 10-14, 2014

Date of Presentation

8-11-2014

Abstract

Novel structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors towards several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while the same compounds produced a weak to moderate activation of α- and β-galactosidases.

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