Title

pH-Sensitive, Ortho Ester-Based Cationic Lipoplexes for Gene Delivery

Document Type

Poster

Department

Chemistry

Conference Title

3rd International Conference on Colloid Chemistry and Physicochemical Mechanics (ICC 2008)

Location

Moscow, Russia

Conference Dates

June 24-28, 2008

Date of Presentation

6-24-2008

Abstract

We report our recent findings on pH-sensitive, ortho ester-based cationic lipids and their lipoplexes for gene delivery. At higher pH, such lipids were relatively stable and readily condensed with plasmid DNA into cationic lipoplexes. At lowered pH, such lipids rapidly hydrolysed, which in turn triggered their lipoplexes to destabilize the endosome membrane.

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