Title

Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations

Document Type

Poster

Department

Chemistry

Conference Title

243rd American Chemical Society (ACS) National Meeting & Exposition

Organization

American Chemical Society (ACS)

Location

San Diego, CA

Conference Dates

March 25-March 29, 2012

Date of Presentation

3-28-2012

Abstract

We suggested recently a novel type of pH-sensitive delivery system, 'fliposomes', which contain trans-2-aminocyclohexanol-based amphiphiles that perform a conformational flip and trigger an instant cargo release in acidic media. Here we report our latest studies on the cellular uptake in HeLa and B16F1 cells of the methotrexate-loaded fliposomes, which indicate that the latter can serve as viable drug delivery systems.

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