Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations
243rd American Chemical Society (ACS) National Meeting & Exposition
American Chemical Society (ACS)
San Diego, CA
March 25-March 29, 2012
Date of Presentation
We suggested recently a novel type of pH-sensitive delivery system, 'fliposomes', which contain trans-2-aminocyclohexanol-based amphiphiles that perform a conformational flip and trigger an instant cargo release in acidic media. Here we report our latest studies on the cellular uptake in HeLa and B16F1 cells of the methotrexate-loaded fliposomes, which indicate that the latter can serve as viable drug delivery systems.
Samoshina, N. M.,
Franz, A. H.,
Samoshin, V. V.
Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations.
Paper presented at 243rd American Chemical Society (ACS) National Meeting & Exposition in San Diego, CA.
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