Title

Trans-2-Aminocyclohexanol-based lipids as pH-sensitive conformational switches for the PEG-grafted liposomes

Document Type

Poster

Department

Chemistry

Conference Title

239th American Chemical Society (ACS) National Meeting

Organization

American Chemical Society (ACS)

Location

San Francisco, CA

Conference Dates

March 21-25, 2010

Date of Presentation

3-24-2010

Abstract

Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: a protonation-induced conformational change of the built-in trans-2-aminocyclohexanol moiety. In liposomes, this ring flip loosens packing of the attached lipid tails, leading to contents leakage. Herein we report our latest studies on the pH-sensitivity of various PEG-grafted (sterically hindered) liposomes comprising trans-2-aminocyclohexanol-based lipids. These liposomes are stable at pH 7.4 and yet release their content in a few seconds at pH 5.3-5.5.

This document is currently not available here.

Share

COinS